Anti-cancer effects of biosynthesized zinc oxide nanoparticles using Artemisia scoparia in Huh-7 liver cancer cells

این مقاله توسط مترجمان و ویراستاران گروه زیست ما ادیت شده و در سال 2022 به چاپ رسیده است.
نویسنده اصلی
فرزانه تفویضی
نام مجله
Inorganic and Nano-Metal Chemistry
سال انتشار
2022
دانلود تصویر صفحه اول مقاله
فرزانه تفویضی

Abstract

This study is aimed to synthesize zinc oxide nanoparticles (ZnO NPs) by Artemisia scoparia extract and explore their cytotoxic behavior against Huh-7 liver cancer cells. The green-synthesized ZnO NPs were investigated using UV–Vis, FT-IR, XRD, TEM, FESEM, EDX, DLS, and Zeta potential. The anti-cancer activity of ZnO NPs and plant extract against cancer cells was evaluated by MTT assay and flow cytometry. The expression of apoptotic genes was assessed by qPCR. The average size of the ZnO NPs was 9.00 ± 4.00 nm. The A. scoparia extract and spherical ZnO NPs both inhibited cell growth and induced apoptosis in Huh-7 cancer cells in a time- and dose-dependent manner. The IC50 values of ZnO NPs and extract were 10.26 and 310.24 µg/mL, respectively. The ZnO NPs also upregulated pro-apoptotic genes while downregulating anti-apoptotic genes. Considering the anti-cancer features of the ZnO NPs, it seems that the green-synthesized ZnO NPs have strong anti-cancer potential


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