The strong increase in the number of installed photovoltaic (PV) production plants has slowly changed the assets and the operating conditions of the electricity power system. In this context, the supply and control of the reactive power from the renewable generation plants are becoming an important issue to be exploited that can facilitate the integration of PV and wind power in electricity grids. The aim of this paper is to propose an optimized control strategy to manage the reactive power resource generated by PV plants in order to improve the quality of the low/medium voltage distribution network and meet the latest technical requirements listed by distribution system operators in their grid codes. A methodology to define the optimal reactive power references for each PV unit connected to a generic distribution network is presented for a specified goal (e.g., the achievement of suitable voltage levels at the grid nodes). Such reference signals are then provided to the PV plants regulation systems, which are designed in order to guarantee the decoupling between the active and reactive power channels, due to the use of the Feedback Linearization control technique. The problem is formulated in a generalized way, so that it can be extended to any possible grid configuration